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Health & Wellness

Evidence-based health, wellness, and longevity content from Dr. Tom Biernacki.

Baicalein and Diabetic Peripheral Neuropathy: RAGE/DIAPH1/Cofilin Axon Growth Cone Rescue, CXCR2/Src/STAT3→Shh/c-Jun Schwann Cell Repair Reactivation, and LOXL2 Endoneurial Fibrosis Reversal

May 26, 2026May 20, 2026 by Dr. Tom Biernacki, DPM, FACFAS
Health supplements and vitamin capsules for daily protocol

Baicalein inhibits pro-inflammatory 12-LOX and protects Schwann cells from oxidative damage. Dr. Tom reviews the evidence base and how baicalein fits into a neuropathy supplement stack.

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Magnesium for Migraines: What a Surgeon Takes (and Why It Works)

May 26, 2026May 20, 2026 by Dr. Tom Biernacki, DPM, FACFAS
Health supplements and vitamin capsules for daily protocol

Magnesium blocks the NMDA receptors that fire during migraine attacks. Dr. Tom breaks down the exact form, dose, and timing he uses — and why most magnesium supplements fail migraine patients.

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Chrysin and Diabetic Peripheral Neuropathy: STOML3/PIEZO2 Allodynia Suppression, eIF2B5 Integrated Stress Response Reversal, and cGAS/STING/TBK1 Endoneurial Innate Immune Silencing

May 26, 2026May 20, 2026 by Dr. Tom Biernacki, DPM, FACFAS
Health supplements and vitamin capsules for daily protocol

Chrysin activates Nrf2 and reduces oxidative stress in diabetic nerve tissue. Dr. Tom reviews the clinical evidence for chrysin in peripheral neuropathy and how it fits into a functional protocol.

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Mold Illness (CIRS): Symptoms, Testing, and the Shoemaker Protocol Explained

May 26, 2026May 20, 2026 by Dr. Tom Biernacki, DPM, FACFAS
Dr. Tom Biernacki presenting his daily supplement protocol — The Private Practice

1 in 4 people can’t clear mycotoxins due to HLA-DR gene variants. Dr. Tom explains CIRS diagnosis, the 12-step Shoemaker protocol, VCS testing, and how to actually recover from mold illness.

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POTS Syndrome: Why Your Doctor Keeps Missing It and What Actually Helps

May 26, 2026May 20, 2026 by Dr. Tom Biernacki, DPM, FACFAS
Dr. Tom Biernacki presenting his daily supplement protocol — The Private Practice

POTS affects 1–3 million Americans, mostly women. Dr. Tom explains orthostatic intolerance, dysautonomia mechanisms, and the functional medicine protocols that actually help.

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Nobiletin and Diabetic Peripheral Neuropathy: CLOCK/BMAL1 Circadian Amplification, HDAC1/PPAR-α Schwann Cell Fatty Acid Oxidation Rescue, and PFKFB3/2,6-BPF Endoneurial Glycolytic Rebalancing

May 26, 2026May 20, 2026 by Dr. Tom Biernacki, DPM, FACFAS
Health supplements and vitamin capsules for daily protocol

Nobiletin, a polymethoxylated flavone from citrus, activates PPAR-γ and reduces TNF-α-driven nerve inflammation. Dr. Tom reviews its role in diabetic peripheral neuropathy management.

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Lyme Disease & PTLDS: Co-Infections, Babesia, Bartonella, and Neuroinflammation

May 26, 2026May 20, 2026 by Dr. Tom Biernacki, DPM, FACFAS
Blood test vials and laboratory equipment for health testing

30,000+ Lyme cases are reported yearly — but chronic Lyme remains contested. Dr. Tom explains coinfection testing, biofilm protocols, immune support, and the integrative approach to post-Lyme syndrome.

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Functional Genomics: APOE4, CYP450, and Precision Medicine Explained

May 26, 2026May 20, 2026 by Dr. Tom Biernacki, DPM, FACFAS
Dr. Tom Biernacki presenting his daily supplement protocol — The Private Practice

Your genome doesn’t determine your destiny — gene expression does. Dr. Tom explains SNP testing, MTHFR, COMT, APOE4, and how nutrigenomics guides personalized supplement protocols.

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Maslinic Acid and Diabetic Peripheral Neuropathy: GSK3β/Tau, CD38/NAD⁺/SIRT1, and SPHK2/S1P2/ROCK2 Mechanisms

May 26, 2026May 19, 2026 by Dr. Tom Biernacki, DPM, FACFAS
Health supplements and vitamin capsules for daily protocol

Maslinic acid, a triterpene from olive skin, inhibits glycation and protects against oxidative nerve damage in diabetes. Dr. Tom reviews the preclinical evidence and protocol use.

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Corosolic Acid and Diabetic Peripheral Neuropathy: WNK1/KCC2, G3BP1/Stress Granules, and RIPK3/MLKL Mechanisms

May 26, 2026May 19, 2026 by Dr. Tom Biernacki, DPM, FACFAS
Health supplements and vitamin capsules for daily protocol

Corosolic acid from banaba leaf mimics insulin action and reduces AGE formation in peripheral nerves. Dr. Tom explains its dual role in blood sugar control and neuropathy protection.

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Recent Posts

  • Baicalein and Diabetic Peripheral Neuropathy: RAGE/DIAPH1/Cofilin Axon Growth Cone Rescue, CXCR2/Src/STAT3→Shh/c-Jun Schwann Cell Repair Reactivation, and LOXL2 Endoneurial Fibrosis Reversal
  • Magnesium for Migraines: What a Surgeon Takes (and Why It Works)
  • Chrysin and Diabetic Peripheral Neuropathy: STOML3/PIEZO2 Allodynia Suppression, eIF2B5 Integrated Stress Response Reversal, and cGAS/STING/TBK1 Endoneurial Innate Immune Silencing
  • Mold Illness (CIRS): Symptoms, Testing, and the Shoemaker Protocol Explained
  • POTS Syndrome: Why Your Doctor Keeps Missing It and What Actually Helps

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