Dr. Tom Biernacki, DPM, FACFAS 
Myo-Inositol for Diabetic Neuropathy: PI(4,5)P₂ Repletion, Schwann Cell Myelination, and Nav1.7 Gene Repression Myo-inositol has an unusual history in diabetic neuropathy research. It was one of the earliest micronutrients studied in DPN — with nerve conduction velocity improvements documented in the 1980s — yet it largely disappeared from clinical conversation when the trials failed to … Read more
Taurine for Diabetic Neuropathy: Osmolyte Competition, ER Calcium, and Glycinergic Disinhibition Taurine is the most abundant free amino acid in peripheral nerve tissue — yet it barely appears in discussions about diabetic neuropathy treatment. That oversight has real clinical consequences. In my practice at Balance Foot and Ankle, I’ve come to view taurine repletion as … Read more
Medically Reviewed by Dr. Tom Biernacki, DPM — Board-Eligible Podiatric Surgeon, Balance Foot & Ankle PLLC, Howell & Bloomfield Hills, Michigan. Dr. Biernacki has performed more than 3,000 foot and ankle surgical procedures and specializes in conservative and surgical management of diabetic peripheral neuropathy. Quick Answer Zinc is chronically deficient in type 2 diabetes — … Read more
Medically Reviewed by Dr. Tom Biernacki, DPM — Board-Eligible Podiatric Surgeon, Balance Foot & Ankle PLLC, Howell & Bloomfield Hills, Michigan. Dr. Biernacki has performed more than 3,000 foot and ankle surgical procedures and specializes in conservative and surgical management of diabetic peripheral neuropathy. Quick Answer Quercetin targets diabetic peripheral neuropathy through three mechanistically independent … Read more
Medically Reviewed by Dr. Tom Biernacki, DPM — Board-Eligible Podiatric Surgeon, Balance Foot & Ankle PLLC, Howell & Bloomfield Hills, Michigan. Dr. Biernacki has performed more than 3,000 foot and ankle surgical procedures and specializes in conservative and surgical management of diabetic peripheral neuropathy. Quick Answer Curcumin targets diabetic peripheral neuropathy through three mechanistically independent … Read more
Medically Reviewed by Dr. Tom Biernacki, DPM — Board-Eligible Podiatric Surgeon, Balance Foot & Ankle PLLC, Howell & Bloomfield Hills, Michigan. Dr. Biernacki has performed more than 3,000 foot and ankle surgical procedures and specializes in conservative and surgical management of diabetic peripheral neuropathy. Quick Answer Resveratrol targets diabetic peripheral neuropathy through three mechanistically independent … Read more
Medically Reviewed by Dr. Tom Biernacki, DPM — Board-Eligible Podiatric Surgeon, Balance Foot & Ankle PLLC, Howell & Bloomfield Hills, Michigan. Dr. Biernacki has performed more than 3,000 foot and ankle surgical procedures and specializes in conservative and surgical management of diabetic peripheral neuropathy. Quick Answer Palmitoylethanolamide (PEA) targets diabetic peripheral neuropathy through three mechanistically … Read more
Medically Reviewed by Thomas Biernacki, DPM — Board-Eligible Podiatric Surgeon, Balance Foot & Ankle · Howell & Bloomfield Hills, MI · Updated May 2026 Quick Answer Berberine — an isoquinoline alkaloid from Berberis and Coptis plants with strong glucose-lowering evidence in type 2 diabetes — also addresses diabetic peripheral neuropathy through three mechanistically independent pathways … Read more
Medically Reviewed by Thomas Biernacki, DPM — Board-Eligible Podiatric Surgeon, Balance Foot & Ankle · Howell & Bloomfield Hills, MI · Updated May 2026 Quick Answer Taurine — a sulfonic amino acid present at the highest concentrations in peripheral nerve tissue of any organ in the body — is dramatically depleted in diabetic nerve by … Read more
Medically Reviewed by Thomas Biernacki, DPM — Board-Eligible Podiatric Surgeon, Balance Foot & Ankle · Howell & Bloomfield Hills, MI · Updated May 2026 Quick Answer Magnesium deficiency affects 25–38% of patients with type 2 diabetes — seven times the general population rate — and directly drives diabetic peripheral neuropathy progression through three independent mechanisms: … Read more