Dr. Tom Biernacki, DPM, FACFAS 
Endothelial dysfunction is the first step in atherosclerosis — measurable years before a calcium score turns positive. Dr. Tom covers flow-mediated dilation, ApoB, Lp(a), and the full advanced cardiac risk panel.
[medical-review-box] Medically Reviewed by Dr. Nnamdi Gwacham, DPM | Board-Certified Podiatrist, Balance Foot & Ankle | Howell, MI & Bloomfield Hills, MI [/medical-review-box] [quick-answer-box] Quick Answer: Fisetin, a plant-derived flavonol, targets diabetic neuropathy through three distinct mechanisms: (1) SIRT3 deacetylation of IDH2 increases mitochondrial NADPH production in DRG neurons, protecting the redox buffer that prevents … Read more
CGM reveals glucose spikes that fasting labs completely miss. Dr. Tom explains how to use continuous glucose monitoring data to identify trigger foods, time exercise, and measure the reversal of metabolic syndrome in real time.
[medical-review-box] Medically Reviewed by Dr. Nnamdi Gwacham, DPM | Board-Certified Podiatrist, Balance Foot & Ankle | Howell, MI & Bloomfield Hills, MI [/medical-review-box] [quick-answer-box] Quick Answer: Palmitoylethanolamide (PEA) reduces diabetic neuropathy pain through three nerve-specific mechanisms: (1) PPAR-α activation in satellite glial cells suppresses FAAH to elevate anandamide and desensitize TRPV1 via PKCε-Ser800 phosphorylation; (2) … Read more
[medical-review-box] Medically Reviewed by Dr. Nnamdi Gwacham, DPM | Board-Certified Podiatrist, Balance Foot & Ankle | Howell, MI & Bloomfield Hills, MI [/medical-review-box] [quick-answer-box] Quick Answer: Palmitoylethanolamide (PEA) reduces diabetic neuropathy pain through three nerve-specific mechanisms: (1) PPAR-α activation in satellite glial cells suppresses FAAH to elevate anandamide and desensitize TRPV1 via PKCε-Ser800 phosphorylation; (2) … Read more
SHBG binds testosterone — high SHBG leaves men symptomatic despite ‘normal’ total testosterone. Dr. Tom covers free testosterone calculation, DHEA-S optimization, prostate health markers, and the complete male hormone panel.
N-Acetylcysteine for Diabetic Neuropathy: TXNIP/ASK1, Fractalkine Macrophage Suppression, and mtDNA Repair N-Acetylcysteine is the most widely used antioxidant precursor in clinical medicine — prescribed in hospital settings for acetaminophen overdose and as a mucolytic for lung disease — but its application in diabetic peripheral neuropathy is underappreciated despite a plausible set of mechanisms that extend … Read more
Selenium for Diabetic Neuropathy: GPx4 Ferroptosis Prevention, Tau Dephosphorylation, and TrxR2/Prx3 Mitochondrial Redox Selenium is the rare micronutrient whose entire biological relevance in nerve tissue flows through a single, genetically encoded amino acid: selenocysteine (Sec), the 21st amino acid incorporated into proteins at UGA codons by the selenocysteine insertion sequence (SECIS) machinery. The 25 human … Read more
EGCG for Diabetic Neuropathy: LRRK2 Inhibition, BDNF Demethylation, and Hyaluronan-TLR4 Blockade Green tea catechins — particularly EGCG (epigallocatechin-3-gallate) — are among the most biochemically promiscuous polyphenols studied in metabolic disease, which is both their clinical challenge and their scientific interest. The challenge: “does everything a little” is a less useful description than “does these three … Read more
Carnosine for Diabetic Neuropathy: AGE Decoy Receptor, Aldehyde Quenching, and Synaptic Zinc Buffering Carnosine is perhaps the most biochemically versatile molecule in the DPN nutraceutical armamentarium — yet it receives less clinical attention than alpha-lipoic acid, benfotiamine, or B vitamins. In my practice at Balance Foot and Ankle, I began incorporating carnosine into DPN protocols … Read more