Dr. Tom Biernacki, DPM, FACFAS 
Medically reviewed by Dr. Tom Biernacki, DPM — Board-eligible podiatric surgeon · Balance Foot & Ankle PLLC · 3,000+ lower-extremity surgeries · Howell & Bloomfield Hills, MI Quick Answer Zinc deficiency is present in 25–38% of diabetic patients and affects peripheral nerve health through three mechanisms that no other longevity supplement addresses: it destabilizes the … Read more
Medically reviewed by Dr. Tom Biernacki, DPM — Board-eligible podiatric surgeon · Balance Foot & Ankle PLLC · 3,000+ lower-extremity surgeries · Howell & Bloomfield Hills, MI Quick Answer Magnesium deficiency affects 48% of adults and is present in over 70% of people with type 2 diabetes — and its consequences for peripheral nerve tissue … Read more
Medically reviewed by Dr. Tom Biernacki, DPM — Board-eligible podiatric surgeon · Balance Foot & Ankle PLLC · 3,000+ lower-extremity surgeries · Howell & Bloomfield Hills, MI Quick Answer Vitamin K2 (as MK-7, menaquinone-7) protects peripheral nerves through three enzyme-specific mechanisms that no other supplement provides: it gamma-carboxylates Gas6, enabling Axl receptor-mediated DRG neuron survival; … Read more
Medically reviewed by Dr. Tom Biernacki, DPM — Board-eligible podiatric surgeon · Balance Foot & Ankle PLLC · 3,000+ lower-extremity surgeries · Howell & Bloomfield Hills, MI Quick Answer Coenzyme Q10 (CoQ10/ubiquinol) reverses three distinct nerve-specific defects in diabetic peripheral neuropathy that no other longevity supplement addresses: it prevents reverse electron transport-driven mtDNA damage at … Read more
Medically reviewed by Dr. Tom Biernacki, DPM — Board-eligible podiatric surgeon · Balance Foot & Ankle PLLC · 3,000+ lower-extremity surgeries · Howell & Bloomfield Hills, MI Quick Answer Acetyl-L-carnitine (ALCAR) reduces diabetic peripheral neuropathy pain scores by an average of 39% over 52 weeks — a magnitude comparable to pregabalin, but without the sedation, … Read more
Medically Reviewed by Thomas Biernacki, DPM — Board-Eligible Foot & Ankle Surgeon, Balance Foot & Ankle PLLC · Howell & Bloomfield Hills, MI · 3,000+ surgical cases Quick Answer Taurine reduces diabetic peripheral neuropathy through three mechanistically independent pathways found in no other supplement in this series: (1) intracellular taurine is incorporated as 5-taurinomethyluridine (τm5U) … Read more
Medically Reviewed by Thomas Biernacki, DPM — Board-Eligible Foot & Ankle Surgeon, Balance Foot & Ankle PLLC · Howell & Bloomfield Hills, MI · 3,000+ surgical cases Quick Answer Sulforaphane — the isothiocyanate from broccoli sprouts — reduces diabetic peripheral neuropathy through three mechanistically independent NRF2-downstream pathways: (1) NRF2/ARE-driven HO-1 transcription generates CO (carbon monoxide), … Read more
Medically Reviewed by Thomas Biernacki, DPM — Board-Eligible Foot & Ankle Surgeon, Balance Foot & Ankle PLLC · Howell & Bloomfield Hills, MI · 3,000+ surgical cases Quick Answer NMN (nicotinamide mononucleotide) and other NAD⁺ precursors reduce diabetic peripheral neuropathy through three mechanistically independent pathways: (1) NAD⁺ repletion suppresses CD38-generated cADPR, preventing RyR2-mediated ER calcium … Read more
Medically Reviewed by Thomas Biernacki, DPM — Board-Eligible Foot & Ankle Surgeon, Balance Foot & Ankle PLLC · Howell & Bloomfield Hills, MI · 3,000+ surgical cases Quick Answer Resveratrol and its more bioavailable analogue pterostilbene reduce diabetic peripheral neuropathy through three mechanistically independent SIRT-axis pathways: (1) SIRT1-mediated p53-K382 deacetylation destabilises p53 and suppresses Noxa/PUMA/Bax … Read more
Medically Reviewed by Thomas Biernacki, DPM — Board-Eligible Foot & Ankle Surgeon, Balance Foot & Ankle PLLC · Howell & Bloomfield Hills, MI · 3,000+ surgical cases Quick Answer Berberine reduces diabetic peripheral neuropathy through three mechanistically independent pathways: (1) AMPK-α1-mediated TXNIP-pY265 phosphorylation blocks NLRP3/caspase-1 pyroptosis and rescues the mature BDNF/TrkB survival axis from ProBDNF/p75NTR … Read more