Omega-3 EPA & DHA for Longevity and Diabetic Neuropathy: Clinical Evidence and Protocol

Health supplements and vitamin capsules for daily protocol

🩺 Medically reviewed by Thomas Biernacki, DPM — Board-certified podiatrist, Balance Foot & Ankle PLLC. 3,000+ surgical cases. Howell & Bloomfield Hills, MI. Updated May 2026. Quick Answer Omega-3 fatty acids EPA and DHA (2–4 g/day combined) protect against diabetic peripheral neuropathy through three independent membrane-to-signaling mechanisms: DHA enrichment of neuronal membranes via LPCAT3 raises … Read more

Omega-3 EPA/DHA Longevity Pathways: LPCAT3, Piezo2, RvE1/ChemR23, and IRF5

Health supplements and vitamin capsules for daily protocol

🩺 Medically reviewed by Thomas Biernacki, DPM — Board-certified podiatrist, Balance Foot & Ankle PLLC. 3,000+ surgical cases. Howell & Bloomfield Hills, MI. Updated May 2026. Quick Answer Omega-3 fatty acids EPA and DHA (2–4 g/day combined) protect against diabetic peripheral neuropathy through three independent membrane-to-signaling mechanisms: DHA enrichment of neuronal membranes via LPCAT3 raises … Read more

Omega-3 EPA/DHA for Diabetic Neuropathy: LPCAT3, Piezo2, RvE1, and Resolvin Signaling

Health supplements and vitamin capsules for daily protocol

🩺 Medically reviewed by Thomas Biernacki, DPM — Board-certified podiatrist, Balance Foot & Ankle PLLC. 3,000+ surgical cases. Howell & Bloomfield Hills, MI. Updated May 2026. Quick Answer Omega-3 fatty acids EPA and DHA (2–4 g/day combined) protect against diabetic peripheral neuropathy through three independent membrane-to-signaling mechanisms: DHA enrichment of neuronal membranes via LPCAT3 raises … Read more

Magnesium Glycinate & L-Threonate for Longevity: TRPM7, AMPK, and Neuropathy

Health supplements and vitamin capsules for daily protocol

🩺 Medically reviewed by Thomas Biernacki, DPM — Board-certified podiatrist, Balance Foot & Ankle PLLC. 3,000+ surgical cases. Howell & Bloomfield Hills, MI. Updated May 2026. Quick Answer Magnesium glycinate or threonate (300–400 mg elemental Mg/day) addresses three independent mechanisms in diabetic peripheral neuropathy: TRPM7-channel/Mg²⁺ entry → AMPK-α2-T172/ACC2-S221 → CPT1/long-chain fatty acid β-oxidation in DRG … Read more

Myo-Inositol for Longevity and Diabetic Neuropathy: KCNQ, mTORC1, and Schwann Cell Repair

Health supplements and vitamin capsules for daily protocol

🩺 Medically reviewed by Thomas Biernacki, DPM — Board-certified podiatrist, Balance Foot & Ankle PLLC. 3,000+ surgical cases. Howell & Bloomfield Hills, MI. Updated May 2026. Quick Answer Myo-inositol (4–8 g/day) reverses the phosphoinositide signaling collapse that hyperglycemia imposes on peripheral nerves through three independent mechanisms: restoring PI(4,5)P2 density at DRG nociceptors to reactivate KCNQ2/KCNQ3 … Read more

Women’s Health: PCOS, Endometriosis, Thyroid, Perimenopause, and DUTCH Testing

Dr. Tom Biernacki presenting his daily supplement protocol — The Private Practice

Quick answer: Women experience autoimmune diseases at 3× the rate of men, struggle with undiagnosed thyroid dysfunction (Hashimoto’s affects 12% of women), and navigate reproductive hormonal transitions where functional medicine offers the most evidence-based, personalized interventions. The DUTCH hormone test, comprehensive thyroid panel beyond TSH, and functional nutrition targeting progesterone deficiency, estrogen detoxification, and the … Read more

Methylcobalamin (B12) for Longevity and Neuropathy: MMACHC, AdoCbl, and Nav1.7

Health supplements and vitamin capsules for daily protocol

🩺 Medically reviewed by Thomas Biernacki, DPM — Board-certified podiatrist, Balance Foot & Ankle PLLC. 3,000+ surgical cases. Howell & Bloomfield Hills, MI. Updated May 2026. Quick Answer High-dose methylcobalamin (1,500 µg/day) improves nerve conduction velocity and reduces neuropathic pain in T2DM patients within 16 weeks — and it works through mechanisms entirely distinct from … Read more

Autoimmunity, Leaky Gut & Hashimoto’s: AIP Diet, Vitamin D, Selenium, and LDN

Dr. Tom Biernacki presenting his daily supplement protocol — The Private Practice

Quick answer: Autoimmune disease affects 50 million Americans — more than cancer and heart disease combined — and is rising at 3–12% annually, a rate far too rapid to be explained by genetics alone. The Autoimmune Protocol (AIP) diet produced clinical remission in 73% of IBD patients in a 2017 pilot study (Konijeti, Inflammatory Bowel … Read more

Chronic Pain & Neuroinflammation: LDN, Central Sensitization, Vitamin D, and Magnesium

Dr. Tom Biernacki presenting his daily supplement protocol — The Private Practice

Quick answer: Chronic pain is not merely a sensory phenomenon — it is a systemic, biologically driven state involving neuroinflammation, central sensitization, gut-brain axis dysbiosis, mitochondrial dysfunction, and vitamin D/magnesium deficiency as modifiable root causes. Low-dose naltrexone (LDN) reduces chronic pain conditions including fibromyalgia by 30% via TLR4 microglial antagonism (Younger 2013, Arthritis & Rheumatology), … Read more

CoQ10 & Ubiquinol for Longevity and Neuropathy: FSP1, Ferroptosis, and Respirasome

Health supplements and vitamin capsules for daily protocol

Medically Reviewed by Thomas Biernacki, DPM — Board-Eligible Podiatric Surgeon, Balance Foot & Ankle PLLC Howell, MI · Bloomfield Hills, MI · 3,000+ lower-extremity surgeries Quick Answer CoQ10 (coenzyme Q10, ubiquinone) — particularly in its reduced ubiquinol form — protects diabetic peripheral nerves through three mechanisms that no other mitochondrial supplement provides. First, ubiquinol is … Read more