Evidence-based health, wellness, and longevity content from Dr. Tom Biernacki.
Intestinal permeability precedes most autoimmune diagnoses by years. Dr. Tom explains the molecular mimicry mechanism, the AIP elimination protocol, and the evidence for low-dose naltrexone in autoimmunity.
Apigenin inhibits CD38 — the enzyme responsible for up to 60% of NAD+ depletion in aging tissues — protecting mitochondrial function in diabetic peripheral nerves. Dr. Tom’s evidence review.
Senescent cells secrete SASP proteins that accelerate every hallmark of aging. Dr. Tom reviews dasatinib + quercetin, fisetin, NAD+ precursors, and the protocols used in longevity medicine today.
50% of men over 50 have BPH and declining testosterone — these aren’t separate problems. Dr. Tom explains the hormone-prostate connection, saw palmetto evidence, and the integrated men’s health workup.
Hesperidin reduces aldose reductase activity and prevents sorbitol accumulation in Schwann cells. Dr. Tom reviews its vascular and neural protective mechanisms in diabetic peripheral neuropathy.
Women’s hormonal disorders share a common root: estrogen-progesterone imbalance driven by insulin resistance and gut dysbiosis. Dr. Tom’s unified functional medicine framework for PCOS, perimenopause, and endometriosis.
TMAO from gut bacteria predicts heart attack risk independent of LDL. Dr. Tom reviews ApoB particle count, coronary artery calcium scoring, and TMAO — the three tests that change cardiovascular management.
95% of serotonin is made in the gut, not the brain — yet psychiatric treatment ignores the gut entirely. Dr. Tom explains the microbiome-brain axis, kynurenine pathway, and functional psychiatry interventions.
Berberine activates AMPK like metformin but also increases BDNF and reshapes the gut microbiome. Dr. Tom reviews berberine’s unique triple mechanism in diabetic neuropathy and why it outperforms many single-target drugs.
VO2 max is the best biomarker of cardiovascular health and longevity. Dr. Tom’s sports medicine approach: VO2 max testing, creatine for power output, and the performance metrics that matter most.